Tablet inonyorova granulation process

Mapiritsi parizvino ndeimwe yeanonyanya kushandiswa mafomu ekuyerwa, ane yakakura kubuda uye inonyanya kushandiswa.Iyo yechinyakare wet granulation process ichiri nzira huru mukugadzirwa kwemishonga.Iyo ine maitiro ekugadzira akakura, yakanaka particle mhando, yakakwirira kugadzirwa kwekuita, uye compression molding.Zvakanaka uye zvimwe zvakanaka, ndiyo inonyanya kushandiswa muindasitiri yemishonga.

Maitiro ekugadzira mahwendefa anogona kazhinji kukamurwa kuita kugadzirwa kwezvinhu zvakasvibirira uye zvekubatsira, kuyera, granulating, kuomesa, kusanganisa, tableting, kupfekedza, nezvimwe. Pane chirevo muindasitiri: granulation ndiye mutungamiri, tableting ndiyo musimboti, uye kurongedza ndeye Phoenix muswe, zvinogona kuonekwa kuti granulation maitiro anoita basa rinokosha mukugadzirwa kwehwendefa rose, asi maitiro ekugadzira zvinhu zvakapfava uye kuwana magranules, kusvika pari zvino pane chirevo chakadzama mumabhuku "kubatisisa bhora, kubata nekuparadzira” , Hazvina kutsanangurwa.Zvichienderana neruzivo rwemunyori mukugadzirwa chaiko, chinyorwa ichi chinoongorora zvinhu zvakati wandei zvinokanganisa kugadzikana kwetablet wet granulation process, uye inopa matanho akakodzera ekudzora kuti ave nechokwadi chemhando yekugadzirwa kwezvinodhaka.

Pretreatment of raw materials

Zvinhu zvakasvibirira uye zvekubatsira zvinowanzoda kudzvanywa uye kuongororwa isati yanyorova kusanganisa uye kugadzira granulation.Zvimwe zvisingakodzeri zviitiko zvinowanzoitika mukugadzirisa tableting, zvakadai sekusaenzana kusanganiswa, kupatsanura, kunamatira kana kuparara, nezvimwewo, zvakanyatsoenderana nekusakwana pulverization fineness yezvinhu zvakasvibirira panguva yekugadzirira.Kana iyo yakasvibirira iri makwapa kana tsono-yakaita sekristaro, mukana wekutsauka pamusoro apa uchave pachena.Iyo skrini ye pretreatment, kupwanya uye kusefa mune yechinyakare maitiro anowanzo 80 mesh kana zana mesh skrini, asi nekufambira mberi kwemidziyo uye mbishi tekinoroji, mazhinji ezvigadzirwa zvakapwanywa kuburikidza ne80 mesh skrini mune yechinyakare maitiro. ikozvino inogona kudarika 100. Mukana wechiitiko chepamusoro chakanyanya kuderedzwa nokuda kwehupfu hwakatsetseka hwakapwanyika kuburikidza ne-100-mesh sieve.Nokudaro, kunaka kwezvinhu zvakasvibirira uye zvekubatsira kuburikidza ne-100-mesh sieve zvishoma nezvishoma zvinotsiva 80-mesh sieving process.

Weighing

Nekuti kuwedzera kana kuderera kwehuremu hwechinhu chimwe nechimwe kunokonzeresa shanduko dzinotevera mune mamwe maitirwo mamiriro, izvo zvinokonzeresa kusagadzikana kweiyo particle quality, izvo zvinogona kukonzera nhevedzano yezvinetso senge tablet chipping, kuwandisa friability, kunonoka kuparara kana kuderedzwa. dissolution, saka pese paunodyisa Mari yacho haigone kugadziriswa zvisina tsarukano.Mumamiriro ezvinhu akakosha, huremu hwekuyera hunofanirwa kusimbiswa zvinoenderana nekuongororwa kwemaitiro.

Kugadzirira kwezvikamu
Mazuva ano, yakakwira-kumhanya kunyorova kusanganisa granulator ndiyo inonyanya kushandiswa midziyo mukugadzira granulation.Kuenzaniswa neyechinyakare musanganisi uye granulator, iyi mhando yegranulator ndeyechokwadi nekuda kwedambudziko remhando yemishonga kana kutsvaga kwemhando yepamusoro.Naizvozvo, iyo granulator haina kubviswa, uye iyo yakakwira-kumhanya yakanyorova kusanganisa granulator inongoshandiswa seyakajairwa musanganiswa, uyezve mamwe mayunifomu granules anowanikwa kuburikidza negranulation.Mamiriro ekuita ayo anokanganisa kunaka kwemagranules akanyorova anonyanya kusanganisira zvinhu zvakawanda senge tembiricha, dosi, nzira yekuwedzera yebhainda, kumhanyisa uye kucheka kumhanya kwegranulator, uye nguva yekukurudzira nekucheka.

Kupisa kwekunamatira
Iyo tembiricha yekunamatira ndiyo yakanyanya kuoma index parameter yekudzora mukukura-up kugadzirwa.Zvinenge zvisingaite kunyatso kudzora kuenderana kwekushisa usati wawedzera adhesive nguva dzese.Naizvozvo, marudzi mazhinji haashandise tembiricha senge indekisi yekudzora, asi mukugadzirwa chaiko, zvinowanikwa kuti tembiricha ye starch slurry ine simba guru pane mamwe marudzi akasiyana.Kune marudzi aya, tembiricha inoda kudiwa zvakajeka.Mumamiriro ezvinhu akajairika, tembiricha yakakwira.Iyo yakakwirira iyo yakaderera adhesion, yakaderera iyo friability yehwendefa;iyo yakakwirira iyo starch slurry tembiricha, iyo yakaderera kunamatira, uye yakakwirira kunyungudika kwehwendefa.Nokudaro, mune mamwe maitiro anoshandisa starch slurry sebhainda, tembiricha yebhainda inofanira kudzorwa kune imwe nhanho.

Kuwanda kwekunamatira

Huwandu hwebhainda hune mhedzisiro yakajeka pazvikamu zvakanyorova, saka huwandu hwayo hunoshandiswawo sechinhu chakakosha chekudzora parameter.Kazhinji, kukura kwehuwandu hwebhainda, kunowedzera kusimba kwechidimbu uye kuoma, asi huwandu hwebhainda hunowanzosiyana nebhechi rezvinhu mbishi uye zvekubatsira.Pachave zvakare nekuchinja kushoma mukusiyana pakati pemhando dzakasiyana, dzinoda kuunganidzwa mukuita kwenguva refu yekugadzira maererano nemhando dzakasiyana.Pakugadzirisa kuoma kwezvinhu zvinyoro, mukati mehutano hunonzwisisika, nzira yekuwedzera huwandu hwebinder iri nani pane nzira yekuwedzera nguva yekusanganiswa.

Concentration of adhesive

Kazhinji, iyo yakakura yekunamatira yakanamatira, iyo yakakura viscosity, iyo isinga patsanurwe kubva muyero yayo.Vazhinji vanogadzira havazosarudze kugadzirisa iyo yekumisikidza kana vawana iyo inonamira yekumisikidzwa mushure mekusimbiswa, asi kudzora iyo yakapfava zvinhu nekugadzirisa huwandu hwekunamatira, kazhinji kusungirira Iyo yekumisikidza iyo mumiririri ichanyorwa seyakatarwa kukosha mukutsanangurwa kwemaitiro uye ichaita. kwete kushandiswa kugadzirisa kunaka kwezvimedu zvakanyorova, saka ini handizozvidzokorora pano.

Nzira yekuwedzera adhesive

Shandisa yakakwirira-kumhanya wet kusanganisa granulation muchina kuti granulate.Kazhinji, kune nzira mbiri dzekuwedzera binder.Imwe ndeyekumisa muchina, kuvhura chivharo chegranulator, uye kudurura binder zvakananga.Nenzira iyi, iyo binder haisi nyore kuparadzira, uye granulation iri Dzimwe nguva zviri nyore kukonzeresa kukwirisa kwenzvimbo uye kusaenzana kwechikamu kusimba.Mhedzisiro ndeyokuti mahwendefa akawedzerwa anoparadzana kana kupedza mutsauko mukuru;imwe yacho inzvimbo isina kumira, kushandisa binder feeding hopper, kuvhura vharafu yekudyisa, uye kubvongodza.Kuwedzera mukuita, iyi nzira yekudyisa inogona kudzivirira kusaenzana kwenzvimbo uye kuita kuti zvidimbu zviwedzere kufanana.Nekudaro, nekuda kwezvinodiwa zverudzi rwebinder, dhizaini dhizaini kana maitiro ekushandisa, nezvimwewo, inomisa kushandiswa kwechipiri nzira yekunyungudika mukugadzira.use.

Sarudzo yekusanganisa kukurumidza uye kukurumidza kutema

Iko kuumbwa kwezvinhu zvakapfava panguva yegranulation yakanangana nekusarudzwa kwekukurumidzira uye kucheka kukurumidza kweiyo yepamusoro-yekukurumidza kusanganisa granulator, iyo ine simba guru pamhando yepellets, uye inobata zvakananga kunaka kweiyo mahwendefa akawedzera.Parizvino, iyo inosimudzira mota yeyakakwira-kumhanya wet kusanganisa granulator ine maviri kumhanya uye inosiyana frequency yekumhanyisa mutemo.Iyo yakapetwa kaviri inopatsanurwa kuita yakaderera kumhanya uye yakakwirira kumhanya.Iyo frequency yekushandura yekumhanyisa control inoshandisa manual kumhanya kudzora, asi bhuku rekukurumidza kudzora rinokanganisa zvimedu kune imwe nhanho.Naizvozvo, iyo yakakwirira-yekumhanyisa yekusanganisa granulator ine frequency yekushandura yekumhanyisa mutemo kazhinji inoseta kumhanya kwekusanganisa uye nguva yekumhanya, uye inotanga otomatiki otomatiki chirongwa kudzikisa mutsauko wevanhu.Kune marudzi ega ega, iyo frequency shanduko ichiri kushandiswa seaviri-kumhanya, asi kune mamwe marudzi akakosha, achimhanya panguva imwe chete, unogona kuwedzera kumhanya kuti uwane yakapfava zvinhu, kuitira kudzivirira kusanganiswa kwenguva refu kunokonzerwa zvinhu zvakapfava zvakanyanyisa.

Sarudzo yekusanganisa uye shredding nguva

A process parameter inokanganisa kunaka kwezvinhu zvakapfava ndiyo nguva yekusanganisa uye shredding.Kumisikidzwa kwemaparamendi ayo kunotaridza zvakananga kubudirira kana kutadza kweiyo granulation process.Kunyange zvazvo kukurumidza kusanganiswa uye shredding speed inogona kugadziriswa ne frequency conversion, zvizhinji zvezvisarudzo zvekugadzirisa zvakagadziriswa Kuti uderedze mutsauko, kuitira kuti uwane humwe hunyoro hwakakodzera, sarudza kuwana chinhu chakakodzera chinyoro nekugadzirisa nguva.Mumamiriro ezvinhu akajairika, kusanganiswa kwenguva pfupi uye kuparadzanisa nguva kuchaderedza kuwanda, kuoma, uye kufanana kwezvikamu, uye kuputika uye kuenzana kusina kukodzera panguva yepiritsi;kusanganiswa kwenguva refu uye shredding nguva ichakonzera kuwanda uye kuoma kwezvikamu Kana zvichiwedzerwa, zvinyorwa zvinyoro zvinogona kukundikana panguva yekumanikidzwa kwepiritsi, nguva yekuparara kwehwendefa ichave yakareba, uye chiyero chekuparara chichave chisina kukodzera.

Granulation midziyo uye granulation matekiniki
Parizvino, kusarudzwa kwemichina yekugezera yekunyorova yakakamurwa kuita yakawanda-inoshanda granulator uye swing granulator.Zvakanakira zveakawanda-function granulator ndeyepamusoro-kushanda uye nyore kushanda uye kushandisa.Kukanganisa ndiko kusiyana kwehuwandu uye nekukurumidza kwekudya nekuda kwekudya kwemaoko., Kufanana kwezvikamu zvishoma kuipa;mukana weiyo swing type granulator ndeyekuti magranules ane yunifomu, uye mutsauko muhuwandu hwekudyisa kwemanyore uye kumhanya kwekudya kudiki.Izvo zvisingabatsiri ndezvekuti kushanda kwakaderera uye kushandiswa kwezvidzitiro zvinoraswa zvinoshandiswa pakubvisa.Kuisa kunenge kuchinetsa.Saizi isina kuenzana inogona kukonzera kuti musiyano upfuure muganho.Iyo mesh nhamba uye kumhanya kweiyo yese particle skrini inogona kudzorwa kuti ivandudze.Kazhinji, kana zvimedu zvakanyorova zvakasimba, unogona kufunga nezvekuwedzera kumhanya, kusarudza yakakura skrini, uye kuderedza huwandu hwekudya nguva yega yega.Kana zvimedu zvakasununguka, unogona kufunga kudzikisa kumhanya, kusarudza diki skrini, uye kuwedzera huwandu hwekudya nguva yega yega.Mukuwedzera, pakusarudza zvidzitiro, kazhinji pane zvidzitiro zvesimbi zvisina tsvina uye nylon skrini yekusarudza kubva.Zvinoenderana neruzivo rwekugadzira uye yakapfava zvinhu zvivakwa, zviri nani kusarudza Stainless simbi skrini ye viscous yakapfava zvinhu, uye yakaoma yakapfava zvinhu.Nylon skrini inonyanya kukodzera, uye iyo swing type granulator inogona zvakare kufunga kusimba kweiyo skrini yekumisikidza kuti igadzirise kuti iwane zvidimbu zvakakodzera.``

Dry

Iyo intuitive embodiment yekuomesa mhedzisiro ndiyo hunyoro hunyoro.The particle mwando chinhu chakakosha chekuongorora chemhando yezvimedu.Iyo inonzwisisika kutonga kweiyi parameter inokanganisa zvakananga kutaridzika uye friability yepiritsi panguva yepiritsi.Mumamiriro ezvinhu akajairika, kuitika kwekuputira panguva yekunyorera kunogona kutariswa kana kunokonzerwa nekuderera kwehunyoro hunyoro, uye kana kunamatira kunoitika panguva yekunyorera, zvinodikanwa kufunga kuti inokonzerwa nehupamhi hwehunyoro hunyoro.Iyo indekisi yekudzora yehunyoro hunyoro inowanzotemwa pakutanga kuburikidza nekuongororwa kwemaitiro, asi hunyoro hunowanzo kunetsa kubereka, uye zvinodikanwa kuunganidza data uye kugadzira hunyoro hwekudzora huwandu.Zvizhinji zvechinyakare nzira dzekuomesa dzinoshandisa kufashaidza kuomesa.Izvo zvinofurira zvinhu zvinosanganisira maitiro maparamendi akadai semhepo yekumanikidza, kupisa tembiricha, nguva yekuomesa, uye huremu hwezvimedu zvakaomeswa.Hunyoro hwezvimedu hunodzorwa neanokurumidza hunyoro analyzer.Mushandi ane hunyanzvi anogona kupfuura nenguva yakareba.Muchiito chekugadzira, hunyoro hwega hwega hwekuomeswa kwezvinhu hunodzorwa mukati meiyo yakanakira renji, iyo inogona kunyatso kuvandudza kugadzirwa kwekuita uye inogona kudzora unyoro zviri nani.Pamusoro pechiitiko chenguva refu, iyo yakakosha data sosi uye nguva yekuomesa uye tembiricha yakaomeswa.

Yese granulation yemagranules akaoma

Zvakangofanana nekunyorova granulation ndeyekuti maitiro maparamita anokanganisa kunaka kweakaoma granules anowanzo iri mesh nhamba uye kumhanya kweiyo granulation skrini.Kuti uve nechokwadi chekugadzirwa kwakatsetseka panguva yetablet, tora yakanyanya kufanirwa particle size kugovera.Uyu ndiwo mukana wekupedzisira wekugadzirisa., Nekusarudza meshes akasiyana uye kumhanya kunotenderera, ichava nemhedzisiro yakakosha pane dzakaomeswa zvimedu.Kazhinji, kana zvimedu zvaoma, sarudza diki skrini, uye kana zvimedu zvakasununguka, sarudza yakakura skrini.Zvisinei, mumamiriro ezvinhu akajairwa, izvi hazvizove sarudzo yemaitiro akakura.Kana iwe uchida kuwana zvirinani zvimedu, iwe uchiri kuda kudzidza nekuvandudza maitiro ekugadzira zvinyoro zvinyoro.

Kusanganisa

Iyo yekusanganisa maitiro maparamendi anobata iyo particle mhando kazhinji huwandu hwemusanganiswa, kumhanya kwemusanganisi, uye nguva yekusanganisa.Kuwanda kwekusanganiswa kunokosha kwakagadziriswa mushure mekusimbiswa kwemaitiro.Iko kumhanya kwemusanganisi kunogona kukanganiswa nekukukurwa kwemusanganisi kumhanya nekuda kwekupfeka kwemidziyo.Kufanana kwekusanganisa kunoda kutariswa kwemidziyo nzvimbo uye nguva nenguva kusimbiswa kwemidziyo isati yagadzirwa.Kuti uve nechokwadi chekufanana kwekusanganiswa kwechidimbu kusvika pamwero mukuru uye kuwana zvigadzirwa zvemhando dzakafanana, zvinodikanwa kuwana nguva yekusanganisa kuburikidza nekuita ongororo.Yakakwana nguva yekusanganisa ivimbiso inoshanda yekuona dhigirii yekupararira kwemafuta muzvikamu zvakaoma, zvikasadaro iyo lubricant inoumba mapoka emagetsi emagetsi panguva yekusanganiswa kwezvimedu zvakaoma, izvo zvinokanganisa kunaka kwezvikamu.

Chirevo:
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Nguva yekutumira: Kubvumbi-20-2021