1. Zvinotarisirwa kuvandudza njodzi yeitsvo uye kufa kubva kuhosha yeitsvo
Chikwata chezvemukati cheWuXi AppTec Medical New Vision yakaburitsa nhau yekuti ongororo yevanhu zviuru gumi yakaratidza kuti metformin inogona kuvandudza njodzi yekutadza kweitsvo uye kufa kubva kuchirwere cheitsvo.
Ongororo yakabudiswa muAmerican Diabetes Association (ADA) magazini "Diabetes Care" (Diabetes Care) yakaratidza kuti kurapwa uye ongororo yekurarama kwevanhu vanopfuura zviuru gumi yakaratidza kuti varwere vane chirwere cheshuga chechipiri vane chirwere cheitsvo chisingaperi (CKD) vanotora Metformin ine chekuita ne kuderedzwa kwenjodzi yekufa uye yekupedzisira-nhanho renal chirwere (ESRD), uye haina kuwedzera njodzi yelactic acidosis.
Chirwere cheitsvo chisingaperi chinowanzoitika kune chirwere cheshuga.Tichifunga kuti varwere vane chirwere cheitsvo chakapfava vanogona kurongerwa metformin, timu yekutsvagisa yakaongorora varwere mazana maviri nemakumi manomwe neina mune rimwe nerimwe remapoka maviri aitora metformin uye kusatora metformin.
Mhedzisiro yacho yakaratidza kuti kana zvichienzaniswa nevaya vasina kutora metformin, varwere vakatora metformin vaive ne35% kuderedzwa kwengozi yezvese-zvinokonzera rufu uye ne33% kuderedzwa kwengozi yekufambira mberi kusvika kumagumo echirwere chetsvo.Aya mabhenefiti akaonekwa zvishoma nezvishoma mushure memakore anenge 2.5 ekutora metformin.
Sekureva kwemushumo, mumakore achangopfuura, iyo US FDA's nhungamiro inokurudzira kuzorora kushandiswa kwemetformin kune varwere vane Type 2 chirwere cheshuga vane chirwere cheitsvo chisingaperi, asi muvarwere vane chirwere cheitsvo.Kune varwere vane mwero (nhanho 3B) uye yakaoma chisingaperi chirwere cheitsvo, kushandiswa kwemetformin kuchiri kukakavara.
Dr. Katherine R. Tuttle, purofesa wepaYunivhesiti yeWashington muUnited States, akati: “Migumisiro yeongororo yacho inonyaradza.Kunyangwe muvarwere vane chirwere cheitsvo chakakomba, njodzi yelactic acidosis yakaderera.Kune varwere vane Type 2 chirwere cheshuga uye chirwere cheitsvo chisingaperi, metformin inogona kunge iri nzira yekudzivirira yekufa uye Mushonga unokosha wekutadza kweitsvo, asi sezvo ichi chiri chidzidzo chekudzokorora uye chekutarisa, mhedzisiro yacho inofanirwa kududzirwa nemazvo.
2. Kurapa kwakasiyana-siyana kwemishonga yemashiripiti metformin
Metformin inogona kunzi mushonga wekare wakagara kwenguva yakareba.Mukuwedzera kwekutsvagisa kwezvinodhaka zve hypoglycemic, muna 1957, musayendisiti wechiFrench Stern akaburitsa tsvakiridzo yake uye akawedzera iro lilac rinobvisa rine hypoglycemic chiitiko mubhinzi dzembudzi.Alkali, inonzi metformin, Glucophage, zvinoreva kuti anodya shuga.
Muna 1994, metformin yakabvumidzwa zviri pamutemo neUS FDA kuti ishandiswe mumhando yechipiri yechirwere cheshuga.Metformin, semushonga une chiremera wekurapa chirwere cheshuga chechipiri, yakanyorwa seyokutanga-mutsara we hypoglycemic drug mune dzakasiyana siyana nhungamiro yekurapa kumba nekune dzimwe nyika.Iyo ine mabhenefiti eiyo chaiyo hypoglycemic effect, yakaderera njodzi ye hypoglycemia, uye yakaderera mutengo.Ikozvino ndiyo inonyanya kushandiswa mishonga Imwe yekirasi yemishonga ye hypoglycemic.
Semushonga wakaedzwa kwenguva, zvinofungidzirwa kuti kune vanopfuura mamirioni zana nemakumi maviri vanoshandisa metformin pasi rese.
Nekudzika kwekutsvagisa, kugona kwekurapa kwemetformin kwakaramba kuchiwedzerwa.Pamusoro pezvichangoburwa zvakawanikwa, metformin yakawanikwawo iine mhedzisiro inosvika makumi maviri.
1. Anti-aging effect
Parizvino, iyo US Food and Drug Administration yakabvumidza muyedzo wekiriniki we "kushandisa metformin kurwisa kuchembera".Chikonzero nei masayendisiti ekunze anoshandisa metformin seanorwisa-kuchembera mushonga anogona kunge ari nekuti metformin inogona kuwedzera huwandu hweokisijeni mamorekuru anoburitswa mumasero.Pamusoro pazvose, izvi zvinoita sezviri kuwedzera kusimba kwemuviri uye kurebesa upenyu.
2. Kuonda
Metformin inhengo ye hypoglycemic inogona kuderedza uremu.Inogona kuwedzera insulin senzwi uye kuderedza mafuta synthesis.Kune vakawanda vanoda shuga yerudzi rwechipiri, kurasikirwa uremu pachayo chinhu chinobatsira kudzora kwakadzikama shuga yeropa.
Ongororo yakaitwa neUnited States Diabetes Prevention Programme (DPP) timu yekutsvagisa yakaratidza kuti munguva yekudzidza isina kuvharwa yemakore 7-8, varwere vakagamuchira metformin vakarasikirwa neavhareji ye3.1 kg muhuremu.
3. Deredza njodzi yekubva pamuviri uye kusununguka nguva isati yakwana kune vamwe vakadzi vane pamuviri
Tsvagiridzo yazvino yakaburitswa muThe Lancet inoratidza kuti metformin inogona kuderedza njodzi yekubva pamuviri uye kuzvara nguva isati yakwana mune vamwe vakadzi vane pamuviri.
Maererano nemishumo, masayendisiti kubva kuNorwegian University of Science and Technology (NTNU) uye St. Olavs Hospital vakaita chidzidzo chemakore anoda kusvika makumi maviri uye vakawana kuti varwere vane polycystic ovary syndrome vanotora metformin pamagumo emwedzi ye3 yekuzvitakura vanogona kuderedza post- term miscarriage and miscarriage.Ngozi yekuzvarwa nguva isati yakwana.
4. Kudzivirira kuzvimba kunokonzerwa nehutsi
Mhedzisiro yechidzidzo ichi yakaratidza kuti timu inotungamirwa naProfessor Scott Budinger weNorthwestern University yakasimbisa mumakonzo kuti metformin inogona kudzivirira kuzvimba kunokonzerwa nehutsi, kudzivirira masero edziviriro kubva pakuburitsa mamorekuru ane njodzi muropa, anodzivirira kuumbwa kwe arterial thrombosis, nekudaro. kuderedza hurongwa hwemwoyo.Ngozi yechirwere.
5. Kudzivirirwa kwemoyo
Metformin ine cardiovascular protective effects uye pari zvino ndiyo yega hypoglycemic drug inokurudzirwa neiyo diabetes nhungamiro seine humbowo hwakajeka hwekubatsira kwemoyo.Zvidzidzo zvakaratidza kuti kurapwa kwenguva refu kwemetformin kwakabatana zvakanyanya nekudzikira kwengozi yechirwere chemoyo mune vachangobva kuongororwa Type 2 chirwere cheshuga uye Type 2 vane chirwere cheshuga vakatogadzira chirwere chemoyo.
6. Kuvandudza polycystic ovary syndrome
Polycystic ovary syndrome chirwere chakasiyana-siyana chinoratidzwa ne hyperandrogenemia, ovarian dysfunction, uye polycystic ovary morphology.Pathogenesis yaro haina kujeka, uye varwere vanowanzova nemadhigirii akasiyana e hyperinsulinemia.Zvidzidzo zvakaratidza kuti metformin inogona kuderedza insulin kuramba, kudzoreredza kuita kwayo ovulation, uye kunatsiridza hyperandrogenemia.
7. Kuvandudza maruva emukati
Zvidzidzo zvakaratidza kuti metformin inogona kudzoreredza chikamu chemaruva emudumbu uye kuita kuti ichinje munzira inokodzera hutano.Inopa nzvimbo yekugara inobatsira kune mabhakitiriya anobatsira mumatumbo, nokudaro kuderedza shuga yeropa uye kugadzirisa zvakanaka maitiro ezvirwere zvemuviri.
8. Zvinotarisirwa kurapa imwe autism
Nguva pfupi yadarika, vaongorori vepaMcGill University vakawana kuti metformin inogona kurapa mamwe mafomu eFragile X syndrome ine autism, uye iyi tsvakiridzo yetsvakiridzo yakaburitswa mujenari Nature Medicine, diki-nyaya yeNature.Parizvino, autism ndeimwe yeakawanda mamiriro ekurapa ayo masayendisiti anotenda kuti anogona kurapwa nemetformin.
9. Reverse pulmonary fibrosis
Vatsvakurudzi veYunivhesiti yeAlabama kuBirmingham vakawana kuti muvarwere vevanhu vane idiopathic pulmonary fibrosis uye mouse pulmonary fibrosis mienzaniso inokonzerwa ne bleomycin, basa re AMPK mu fibrotic tissues rakaderedzwa, uye mishonga inopikisa masero The apoptotic myofibroblasts yakawedzera.
Kushandisa metformin kumisa AMPK mumyofibroblasts kunogona kuita kuti maseru aya awedzere kuapoptosis.Uyezve, mumuenzaniso wembeva, metformin inogona kumhanyisa kubviswa kweiyo yakatogadzirwa fibrotic tishu.Ichi chidzidzo chinoratidza kuti metformin kana mamwe AMPK agonist anogona kushandiswa kudzosera fibrosis yakatoitika.
10. Batsira pakurega kusvuta
Vatsvakurudzi veYunivhesiti yePennsylvania vakawana kuti kushandiswa kwenguva refu kwe nicotine kunogona kutungamirira kukushandiswa kwenzira yekuratidzira AMPK, iyo inodziviswa panguva yekubvisa nicotine.Nokudaro, vakagumisa kuti kana mishonga inoshandiswa kumisa nzira yekucherechedza AMPK, inogona kuderedza mhinduro yekurega.
Metformin ndeye AMPK agonist.Apo vatsvakurudzi vakapa metformin kune mbeva dzaive nekubvisa nicotine, vakaona kuti yakabvisa kubviswa kwemakonzo.Tsvagiridzo yavo inoratidza kuti metformin inogona kushandiswa kubatsira kurega kuputa.
11. Anti-inflammatory effect
Kare, preclinical uye kiriniki zvidzidzo zvakaratidza kuti metformin haingogone kuvandudza kuzvimba kusingaperi nekuvandudza metabolic parameters senge hyperglycemia, insulin resistance uye atherosclerotic dyslipidemia, asi zvakare ine yakananga anti-inflammatory effect.
Zvidzidzo zvakaratidza kuti metformin inogona kurambidza kuzvimba, kunyanya kuburikidza neAMP-activated protein kinase (AMPK)-inotsamira kana yakazvimirira inhibition yenyukireya transcription factor B (NFB).
12. Reverse cognitive impairment
Vatsvagiri vepaYunivhesiti yeTexas kuDallas vakagadzira modhi yembeva inotevedzera marwadzo ane chekuita nekusagadzikana kwepfungwa.Vakashandisa modhi iyi kuyedza kushanda kwemishonga yakawanda.
Mhedzisiro yekuedza inoratidza kuti kurapwa kwemakonzo ane 200 mg/kg uremu hwemuviri wemetformin kwemazuva 7 kunogona kudzoreredza zvachose kukanganisa kwekuziva kunokonzerwa nekurwadziwa.
Gabapentin, iyo inobata neuralgia uye pfari, haina mhedzisiro yakadaro.Izvi zvinoreva kuti metformin inogona kushandiswa semushonga wekare kurapa kusagadzikana kwekuziva kune varwere vane neuralgia.
13. Kudzivisa bundu kukura
Mazuva mashoma apfuura, maererano neSingularity.com, nyanzvi kubva kuEuropean Institute of Oncology dzakaona kuti metformin nekutsanya zvinogona kushanda zvakabatana kudzivirira kukura kwemamota emakonzo.
Kuburikidza nekumwe tsvagiridzo, zvakaonekwa kuti metformin nekutsanya inhibit bundu kukura kuburikidza nePP2A-GSK3β-MCL-1 nzira.Tsvagiridzo yakaburitswa paCancer Cell.
14. Inogona kudzivirira macular degeneration
Dr. Yu-Yen Chen anobva kuTaichung Veterans General Hospital muTaiwan, China munguva pfupi yapfuura akawana kuti chiitiko chezera-related macular degeneration (AMD) kune varwere vane chirwere cheshuga 2 vanotora metformin zvakanyanya kuderera.Izvi zvinoratidza kuti uchidzora chirwere cheshuga, iyo anti-kuzvimba uye antioxidant mabasa emetformin ane inodzivirira pa AMD.
15. Kana kuti inogona kurapa kurasikirwa kwebvudzi
Chikwata chaHuang Jing, sainzi wechiChinese paYunivhesiti yeCalifornia, Los Angeles, chakawana kuti zvinodhaka zvakaita semetformin uye rapamycin zvinogona kumutsa bvudzi muchikamu chekuzorora chembeva kupinda muchikamu chekukura uye kukurudzira kukura kwebvudzi.Tsvagiridzo inoenderana yakatsikiswa mupepanhau redzidzo rine mukurumbira Cell Reports.
Zvakare, masayendisiti paakashandisa metformin kurapa varwere vane polycystic ovary syndrome muChina neIndia, vakaonawo kuti metformin ine chekuita nekudzikira kwebvudzi.
16. Reverse biological age
Munguva pfupi yapfuura, webhusaiti yepamutemo yepasi rose sainzi uye tekinoroji magazini "Nature" yakaburitsa blockbuster nhau.Mishumo inoratidza kuti chidzidzo chidiki chekiriniki muCalifornia chakaratidza kwekutanga kuti zvinokwanisika kudzosera munhu epigenetic wachi.Mugore rapfuura, vapfumbamwe vakazvipira vane hutano vakatora musanganiswa wekukura kwehomoni nemishonga miviri yechirwere cheshuga, kusanganisira metformin.Zvichiyerwa nekuongorora zvibodzwa pajenome remunhu, zera ravo rekubereka radzika neavhareji yemakore maviri nehafu.
17. Mushonga wakasanganiswa unogona kurapa kenza yemazamu ine katatu isina kunaka
Mazuva mashoma apfuura, chikwata chinotungamirirwa naDr. Marsha rich rosner weUniversity of Chicago chakaona kuti kusanganiswa kwemetformin nemumwe mushonga wekare, heme (panhematin), unogona kunangana nekurapa kenza yemazamu ine katatu isina kunaka iyo inotyisidzira zvakanyanya hutano hwevakadzi. .
Uye pane humbowo hwekuti zano rekurapa iri rinogona kushanda kune akasiyana siyana ecancer sekenza yemapapu, kenza yeitsvo, gomarara rechibereko, kenza yeprostate uye acute myeloid leukemia.Tsvagiridzo inoenderana yakaburitswa mumagazini yepamusoro Nature.
18. Inogona kuderedza migumisiro yakaipa yeglucocorticoids
Munguva ichangopfuura, "The Lancet-Diabetes and Endocrinology" yakabudisa chidzidzo-migumisiro yeongororo yakaratidza kuti muchikamu chechipiri chekuedza kwekliniki, metformin inoshandiswa kune varwere vane zvirwere zvisingaperi zvinopisa zvinogona kuvandudza hutano hwemagetsi uye kuderedza kurapa kweglucocorticoid Serious side effects.
Ongororo dzakaratidza kuti metformin inogona kuita kuburikidza neakakosha metabolic protein AMPK, uye nzira yekuita inonyatso kupesana neglucocorticoids, uye ine mukana wekudzosera mhedzisiro inokonzerwa nekushandiswa kukuru kweglucocorticoids.
19. Tariro yekurapa multiple sclerosis
Kare, timu yekutsvagisa inotungamirwa naRobin JM Franklin weYunivhesiti yeCambridge uye mudzidzi wake Peter van Wijngaarden vakaburitsa chinyorwa mupepanhau repamusoro "Cell Stem Cells" kuti vakawana yakasarudzika rudzi rwekuchembera neural stem masero anogona kupora mushure mekurapwa. metformin.Mukupindura kusiyanisa-kukurudzira zviratidzo, inoratidzikazve simba revechidiki uye inowedzera kukurudzira kuvandudzwa kwemyelin nerve.
Kuwanikwa uku kunoreva kuti metformin inotarisirwa kushandiswa mukurapa zvirwere zvisingachinjiki zvine chekuita neurodegeneration, senge multiple sclerosis.
Nguva yekutumira: Kubvumbi-21-2021